« 調香の考え方と技術について | Main | 第64回日本循環器心身医学会に参加して »

October 27, 2007


Grapefruit juice gets anti-cancer fillip


Grapefruit juice and its active components, furocoumarins, may inhibit cytochrome P450 enzymes involved in the activation of compounds into cancer-causing compounds, suggests new research from the US.


Researchers from Texas A&M University report that extracts from grapefruit juice could inhibit the enzymes at concentrations of 25 per cent or lower,


"Grapefruit juice bioactive components may act as potent inhibitors of cytochrome P450 enzymes that are involved in activation procarcinogen to carcinogen," wrote the authors in the Journal of Food Science.

「グレープフルーツ・ジュースの生理活性成分は、癌原物質を癌物資へ活性化することに関与するチトクロームP450酵素の有効な阻害剤として働くかも知れない」と、Food Scienceジャーナルの著者が書いた。

procarcinogen 癌原物質

"This represents a unique mechanism in the anticarcinogenesis strategy, part of which includes reducing the generation of reactive oxygen species."


anticarcinogenesis 抗がん性物質

Grapefruit contain flavonoids, which have received much attention because of their ability to scavenge free radicals. Recently, American and Chinese researchers reported that one specific flavonoid, naringenin, has anti-cancer effects beyond that of an antioxidant (Journal of Nutritional Biochemistry, Vol. 17, pp. 89-95).


Another study from Israeli scientists reported that eating a red grapefruit daily could lower blood cholesterol by 15 per cent (Journal of Agricultural and Food Chemistry, doi:10.1021/jf058171g).


The new study investigated the effects of grapefruit and its active components on the activity of different enzymes in the cytochrome P450 group. These enzymes are involved in the metabolism and detoxification of many environmental carcinogens, fatty acids, fat soluble vitamins, and 60 per cent of currently-marketed drugs, stated the researchers.


Lead researcher B.S. Patel and co-workers looked at the enzyme inhibiting effects of seven different grapefruit and pummelo juices, in addition to five furocoumarins isolated from grapefruit juice - paradisin A, dihydroxybergamottin, bergamottin, bergaptol, and geranylcoumarin.

主任研究者のB.S. Patelらは、異なる7のグレープフルーツおよびポメロジュース、さらにグレープフルーツ・ジュースより単離したフロクマリン― paradisin A、dihydroxybergamottin、ベルガモチン、bergaptolおYOBI
geranylcoumarin の酵素阻害作用を調べた。

They report that both juices inhibited cytochrome CYP3A4 and CYP2C9 isoenzymes at a concentration of 25 per cent, while inhibition of the CYP2D6 isoenzyme was less at all the concentrations tested.



Moreover, paradisin A was reported to be the most active inhibitor amongst the furocoumarins. This was followed by dihydroxybergamottin, bergamottin, bergaptol, and geranylcoumarin, respectively.

さらに、paradisin Aはフロクマリン類のなかで最も活性がある阻害剤であると報告された。それぞれ、これの後にdihydroxybergamottin、ベルガモチン、bergaptolとgeranylcoumarinが続いた。

"Inhibition of cytochrome P450 enzymes by grapefruit juices and its furocoumarins offers some clinical advantages in improving bioavailability of poorly absorbed drugs and reduce the dose requirements and ultimately reducing the cost and harnessing the health benefits of consuming grapefruit juice," stated the researchers.



« 調香の考え方と技術について | Main | 第64回日本循環器心身医学会に参加して »


Post a comment

(Not displayed with comment.)

Comments are moderated, and will not appear on this weblog until the author has approved them.


TrackBack URL for this entry:

Listed below are links to weblogs that reference グレープフルーツジュース成分フロクマリン物質の発がん化阻害:

» 「グレープフルーツ」 に関する口コミ、評判、ショッピング情報のブログリンク集 [ブログの口コミ、評判、いい商品!]
グレープフルーツでの検索結果をマッシュアップして最新ブログからの口コミや評判、ショッピング情報をまとめています [Read More]

Tracked on November 16, 2007 at 05:20 AM

« 調香の考え方と技術について | Main | 第64回日本循環器心身医学会に参加して »