オメガ-3脂肪酸の抗喘息作用

Omega-3 EPA triumphs over in DHA for anti-asthma potential: Study

オメガ-３は抗喘息の可能性でDHAに勝利する：研究

The omega-3 fatty acid EPA (eicosapentaenoic acid) is a more potent inflammation inhibitor than DHA (docosahexaenoic acid), says a new Anglo-American study.

オメガ-３脂肪酸EPA(エイコサペンタエン酸)はDHA(ドコサヘキサエン酸)より強力な炎症抑制剤であると新アングロ・アメリカン研究は述べている。

eicosapentaenoic acid:エイコサペンタエン酸
docosahexaenoic acid ドコサヘキサエン酸

Writing in the journal Clinical Nutrition, scientists from Indiana University (US) and Loughborough University (UK) report that EPA and EPA-rich media reduced markers of inflammation more that DHA and DHA-rich media when tested in cells obtained from asthmatic patients.

インディアナ大学（米国）およびラフバラ大学（英国）科学者の学術誌臨床栄養学の記事はEPA および EPA豊富な中膜は、喘息患者から入手した細胞の検査してみると、DHA and DHA豊富な媒体より炎症マーカーを減少させたと報告している。。

“The present study has shown for the first time that EPA is a more potent inhibitor than DHA of inflammatory responses in human asthmatic … cells,” wrote lead author Timothy Mickleborough.

「本研究は、ＥＰＡがヒトの喘息細胞でDHAの炎症反応よりより強力な阻害剤であることを初めて示した」と、主任著Timothy Mickleboroughが書いた。

“The clinical relevance of the present study, along with previous work from our group, suggest that EPA-rich fish oil may provide a therapeutic option for adults with asthma.In view of the clinical consequences, these findings point towards prophylactic and acute therapeutic effects of fish oil supplementation in inflammatory diseases such as asthma.”

「本研究の臨床関連は、我々のグループの以前の研究に沿って、EPAが成人喘息患者に対して治療的なオプションを提供するかもしれないことを示唆している。臨床結果を鑑みて、これらの知見は、喘息のような炎症性疾患で魚油サプルメントの予防および急性治癒作用を指している。」

Study details

The Anglo-American researchers obtained cells from the lungs of 21 asthmatic adults. The cells were then cultured in different media, including pure EPA, EPA-rich media (Epax 4510 TG), DHA, DHA-rich media (Epax 1050 TG), an omega-6 media, or a control media.

The markers of inflammation measured by Mickleborough and his co-workers included leukotriene (LT)B4, prostaglandin (PG)D2, tumor necrosis factor-alpha (TNF-a) and interleukin (IL)-1beta production.

Both the pure EPA and the EPA-rich media were found to suppress production of TNF-a, IL-1beta , PGD2, and LTB4 to a much greater extent than either DHA media, said the researchers.

“The present study has shown that the greater the EPA content of a fish oil formulation the greater the inhibition of the inflammatory response,” wrote Mickleborough and his co-workers.

“Elucidating the mechanism of this modulation could help us to understand how dietary omega-3 PUFA achieves their specific effects on airway inflammation in asthmatic individuals.”

According to the European Federation of Allergy and Airway Diseases Patients Association (EFA), over 30m Europeans suffer from asthma, costing Europe €17.7bn every year. The cost due to lost productivity is estimated to be around €9.8bn.