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February 23, 2013


Light in the built environment: potential role of circadian disruption in endocrine disruption and breast cancer.


built environment 建造環境
endocrine disruption 内分泌攪乱


Cancer Causes Control. 2001 Apr;12(3):279-87.

Stevens RG, Rea MS.


University of Connecticut Health Center, Department of Community Medicine, Farmington 06030-6325, USA.



Life in industrialized societies is primarily life inside buildings. Illumination from electric lighting in the built environment is quite different from solar radiation in intensity, spectral content, and timing during the 24-hour daily period.


electric lighting 電気照明
solar radiation 日射,太陽放射
intensity 輝度

Humans evolved over millions of years with the day-night pattern of solar radiation as the primary circadian cue. This pattern maintained a 24-hour rhythm of melatonin release, as well as a host of other physiological rhythms including the sleep-wake cycle.


sleep-wake cycle 睡眠-覚醒サイクル

Electric lighting in the built environment is generally more than sufficient for visual performance, but may be inappropriate for the maintenance of normal neuroendocrine rhythms in humans; e.g., insufficient during the day and too much at night. Lighting standards and engineering stress visual performance, whereas circadian function is not currently emphasized.


more than sufficient
visual perforformance 視作業; 見え方
neuroendocrine rhythms 神経内分泌リズム

The molecular biological research on the circadian clock and on mechanisms of phototransduction makes it clear that light for vision and light for circadian function are not identical systems. In particular, if electric lighting as currently employed contributes to 'circadian disruption' it may be an important cause of 'endocrine disruption' and thereby contribute to a high risk of breast cancer in industrialized societies.

circadian clock 概日時計
phototransduction 光伝達


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February 21, 2013


Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats.


sympathetic markers 交感神経マーカー
plasma melatonin 血しょうメラトニン


J Neurochem. 2006 Jun;97(5):1279-87. Epub 2006 Mar 15.

Dagnino-Subiabre A, Orellana JA, Carmona-Fontaine C, Montiel J, Díaz-Velíz G, Serón-Ferré M, Wyneken U, Concha ML, Aboitiz F.


Department of Psychiatry and Center for Medical Research, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.



Chronic stress affects brain areas involved in learning and emotional responses. Although most studies have concentrated on the effect of stress on limbic-related brain structures, in this study we investigated whether chronic stress might induce impairments in diencephalic structures associated with limbic components of the stress response.


diencephalic structures 間脳の構造

Specifically, we analyzed the effect of chronic immobilization stress on the expression of sympathetic markers in the rat epithalamic pineal gland by immunohistochemistry and western blot, whereas the plasma melatonin concentration was determined by radioimmunoassay.


chronic immobilization stress 慢性固定ストレス
epithalamic 視床上部の
immunohistochemistry 免疫組織化学

We found that chronic stress decreased the expression of three sympathetic markers in the pineal gland, tyrosine hydroxylase, the p75 neurotrophin receptor and alpha-tubulin, while the same treatment did not affect the expression of the non-specific sympathetic markers Erk1 and Erk2, and glyceraldehyde-3-phosphate dehydrogenase.

我々は、慢性ストレスが松果体の3つの交感神経マーカー(チロシン水酸化酵素、p75ニューロトロフィン受容体、アルファチュブリン)の発現を減少させて、一方、同じ処置は非特異的交感神経マーカーERK1(細胞外シグナル制御キナーゼ1)とERK2、およびグリセルアルデヒド-3 - リン酸脱水素酵素の発現に影響を与えなかった。

tyrosine hydroxylase チロシン水酸化酵素、
the p75 neurotrophin receptor p75ニューロトロフィン受容体
alpha-tubulin アルファチュブリン
ERK1:extracellular signal-regulated kinase 1細胞外シグナル制御キナーゼ 1
glyceraldehyde-3-phosphate dehydrogenase グリセルアルデヒド-3-リン酸デヒドロゲナーゼ (NADP+)

Furthermore, these results were correlated with a significant increase in plasma melatonin concentration in stressed rats when compared with control animals. Our findings indicate that stress may impair pineal sympathetic inputs, leading to an abnormal melatonin release that may contribute to environmental maladaptation. In addition, we propose that the pineal gland is a target of glucocorticoid damage during stress.


evironmental maladaptation.環境不適応


私たちの食べ物の中に含まれるフェニルアラニンやチロシンというアミノ酸がチロシン水 酸化酵素によってドーパになり、それがドーパ脱炭酸酵素の働きでドーパミンになることがわかっています。







人間の松果体の胞には、脳砂と呼ばれる砂のような物質が含まれる。化学的には、リン酸カルシウム、炭酸カルシウム、リン酸アンモニウムからなる[1]。 最近では、方解石の沈殿物も報告されている



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February 17, 2013


Stress, cancer and circadian rhythm of melatonin



Pathol Biol (Paris). 2005 Jun;53(5):269-72. Epub 2005 Jan 20.

Kwiatkowski F, Abrial C, Gachon F, Chevrier R, Curé H, Chollet P.


Centre Jean-Perrin, 58, rue Montalembert, 63011 Clermont-Ferrand, France. Fabrice



Influence of stress on immunity and pathogenesis relates to corticotropic axis: hypothalamus-hypophysis-surrenals (HHS). Its over-stimulation due to traumas during early childhood or before birth seems to generate brain abnormalities such as reduction of hippocampus volume.


corticotropic axis 副腎軸

More typical of adult age, hypothalamus-pineal gland axis (HP), responsible for melatonin production, may be impaired because of chronic stress, mainly through sleep disturbances or addictive behaviours. Old age has been reported to produce same impairments.

メラトニン産生のもとになる典型的成年期の視床下部 - 松果体軸(HP)は主に睡眠障害または嗜癖行動を通して慢性的ストレスために損なわれるかもしれない。老後も同じ障害を産生することが報告された。

addictive behaviours  嗜癖行動
Immunotherapy 免疫療法

Circadian cycle of melatonin is closely related to immune functions and its disturbance seems to induce, among populations undergoing frequent changes of life rhythm, a significant raise of cancer incidence: night shift workers, air pilots... Stress then seems enable to increase cancer risk through its negative impact on HHS and HP axis and therefore on immunity.

メラトニンの概日周期が密接に免疫機能と関係しており、その障害は、生活リズムの頻繁な変化を受ける個体群(夜間勤務者、パイロット)でがん発症の有意な増加を誘発するようである。 その次に、ストレスは視床下部・脳下垂体・腎上体(HHS)と視床下部 - 松果体軸(HP)に、従って、免疫にストレスの負の影響を通してがんのリスクを増大させることを可能にするようである。


Immunotherapy, which was an interesting solution considering this, has not yield yet expected results. Upstream, other ways have been successfully investigated in prospective randomised trials, such as psychotherapeutic treatments, with positive effects on cellular immunity and survival. The ability to condition immune responses in animals allows thinking that hypnotherapy could also be used along with standard treatments.

Immunotherapy 免疫療法
prospective randomised trials 前向き無作為化試験
cellular immunity 細胞性免疫
cellular survival 細胞生存



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February 12, 2013


Nobel Prize in Chemistry 2012: Smart Receptors On Cell Surfaces


The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2012 to Robert J. Lefkowitz Howard Hughes Medical Institute and Duke University Medical Center and Brian K. Kobilka Stanford University School of Medicine "for studies of G-protein-coupled receptors."

スウェーデン王立科学アカデミーは2012年のノーベル化学賞を、Gタンパク質共役受容体に対してハワード・ヒューズ医学研究所とデューク大学医学校のRobert J. Lefkowitz博士、スタンフォード大学医学校のBrian K. Kobilka博士へ授与することを決定した。

G-protein-coupled receptors Gタンパク質共役受容体(ジータンパクしつきょうやくじゅようたい)

Your body is a fine-tuned system of interactions between billions of cells. Each cell has tiny receptors that enable it to sense its environment, so it can adapt to new situtations. Robert Lefkowitz and Brian Kobilka are awarded the 2012 Nobel Prize in Chemistry for groundbreaking discoveries that reveal the inner workings of an important family of such receptors: G-protein-coupled receptors.

あなたの体は、数十億の細胞間の相互作用で微調整されるシステムです。それぞれの細胞は新しい状況に適用できるようにその環境を感知できる小さな受容体を有しています。そのような受容体の重要なファミーリー・Gタンパク質共役受容体の細胞内の働きを解明する草分け的な発見に対して2012年のノーベル化学賞はRobert Lefkowitz博士とBrian Kobilka博士に授与される。

For a long time, it remained a mystery how cells could sense their environment. Scientists knew that hormones such as adrenalin had powerful effects: increasing blood pressure and making the heart beat faster. They suspected that cell surfaces contained some kind of recipient for hormones. But what these receptors actually consisted of and how they worked remained obscured for most of the 20th Century.


Lefkowitz started to use radioactivity in 1968 in order to trace cells' receptors. He attached an iodine isotope to various hormones, and thanks to the radiation, he managed to unveil several receptors, among those a receptor for adrenalin: β-adrenergic receptor. His team of researchers extracted the receptor from its hiding place in the cell wall and gained an initial understanding of how it works.


iodine isotope ヨウ素同位元素

The team achieved its next big step during the 1980s. The newly recruited Kobilka accepted the challenge to isolate the gene that codes for the β-adrenergic receptor from the gigantic human genome. His creative approach allowed him to attain his goal. When the researchers analyzed the gene, they discovered that the receptor was similar to one in the eye that captures light.


They realized that there is a whole family of receptors that look alike and function in the same manner.Today this family is referred to as G-protein-coupled receptors. About a thousand genes code for such receptors, for example, for light, flavour, odour, adrenalin, histamine, dopamine and serotonin. About half of all medications achieve their effect through G-protein-coupled receptors.The studies by Lefkowitz and Kobilka are crucial for understanding how G-protein-coupled receptors function.

彼らは同じように見えて同じ方法で機能する全体ファミリー受容体であることを気づきました。今日では、このファミリーはGタンパク質共役型受容体とも呼ばれています。例えば、約1000もの遺伝子が光、味、香り、アドレナリン、ヒスタミン、ドパミン、セロトニンなどの受容体にコードされています。全ての薬剤の半数がGタンパク質共役型受容体を通してそれらの作用を達成します。Lefkowitz および Kobilkaによる研究は如何にGタンパク質共役型受容体が機能するかを理解するために極めて重要であります。










香りの科学はどこまで解明されたかーアロマテラピー・森林浴・嗜好飲料 , フレグランスジャーナル社, 2007年



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February 08, 2013


Medicine Cards: 24 - Crow: Law


Crow…         カラスよ
Are you “cawing”,  あなたは“カーカー鳴いて”いるのですか
So I may know  だから私は知っているかもしれない
The secrete of balance, バランスの秘密
Within my soul?  私の内なる魂

Or are you sending, または、あなたは送信しているのですか
Your sacred “caw”      あなたの聖なる“カーカーいう鳴き声”
Just to remind me,   まさに私は思い出します
Of universal laws? 普遍的法則について

There is a medicine story that tells of Crow's fascination with her own shadow.She kept looking at it, scratching it, pecking at it, until her shadow woke up and became alive. Then Crow's shadow ate her. Crow is Dead Crow now.


Dead Crow is the Left-Handed Guarding. If you look deeply into Crow's eye, youwill have found the gateway to the supernatural. Crow knows the unknowable mysteries of creation and is the keeper of all sacred law.


sacred law 聖法

Since Crow is the keeper of sacred law, Crow can bend the laws of the physical universe and "shape shift." This ability is rare and unique. Few adepts exist in today'sworld, and fewer still have mastered
Crow's art of shape shifting. This art includesdoubling, or being in two places at one time consciously;
taking on another physical form, and becoming the "fly on the wall" to observe what is happening far away.


physical univese 物質界
a fly on the wall:壁に止まっているハエ(人に気づかれずに観察する人.)

The Europeans that came to Turtle Island were named the "boat people" by Slow Turtle. Even with
the knowledge of alchemy possessed by certain boat people, none had ever seen the powerful shape shifting of shamans who utilized Crow medicine. Many boat people were frightened by what appeared to be animals
coming into their camps or dwellings to discern their medicine. Crow medicine people are masters of illusion.


All sacred texts are under the protection of Crow. Creator's Book of Laws or Book of Seals is bound in Crow feathers. Crow feathers tell of spirit made flesh. Crow is also the protector of the "ogallah" or ancient records.


ogallah オガラ

The Sacred Law Belts, or Wampum Belts, beaded by native women long before the boat people or Europeans came to this continent, contain knowledge of the Great Spirit's laws, and are kept in the Black Lodges, the
lodges of women. The law which states that "all things are born of women," is signified by Crow.

ボートピープルまたはヨーロッパ人がこの大陸へ来るはるか前にネイティブ・アメリカンの女性によってビーズで飾った聖なる法則のベルト、またはWampum Beltsはグレイト・スピリットの法則の知識を含んでいて、女性ロッジ・ブラックロッジに保管されています。“全ての物は女性から生まれる”と述べている法則はカラスによって示されています。

Children are taught to behave according to the rules of a particular culture. Most orthodox religious
systems create a mandate concerning acceptable behavior within the context of worldly affairs. Do this
and so, and you will go to heaven. Do thus and so, and you will go to hell. Different formulas for
salvation are demanded by each "truefaith."


orthodox religious systems 正統派宗教制度
worldly affairs世事, 俗事, 〈俗事〉・風塵

Human law is not the same as Sacred Law. More so than any other medicine, Crow sees that the physical
world and even the spiritual world, as humanity interprets them, are an illusion. There are billions of
world. There are an infinitude of creatures. Great Spirit is with all. If an individual obeys Crow's
perfect laws as given by the Creator, then at death, he or she dies a Good Medicine death - going on to
the next incarnation with a clear memory of his or her past.


Crow is an omen of change. Crow lives in the void and has no sense of time. The Ancient Chiefs tell us that Crow sees simultaneously the three fates - past, present, and future. Crow merges light and darkness, seeing both inner and outer reality.


If Crow medicine appears in your card spread, you must pause and reflect on how you see the laws of the Great Spirit in relation to the laws of humanity. Crow medicine signifies a firsthand knowledge of a higher order of right and wrong than that indicated by the laws creaed in human culture. With Crow medicine, you speak in a powerful voice when addressing issues that for you seem out of harmony, out of balance, out of whack, or unjust.


Remember that Crow looks at the world with first one eye, and then the other cross-eyed. In the Mayan culture, cross-eyeds had the privilege and duty of looking into the future. You must put aside your fear of being a voice in the wilderness and "caw" the shots as you see them.


As you learn to allow your personal integrity to be your guide, your sense of feeling alone will vanish.
Your personal will can then emerge so that you will stand in your truth. The prime path of true Crow
people says to be mindful of your opinions and actions. Be willing to walk your talk, speak your truth, know your life's mission, and balance past, present, and future in the now. Shape shift that old reality and become your future self. Allow the bending of physical laws to aid in creating the shape shifted world
of peace.



So you are an outlaw today, eh? This is one of the varied messages of Crow reversed. The rebel in you has given a yell, and all hell is about to break loose!

したがって、今日、あなたはならず者です、えっ? これは逆転したカラスの幾つかのメッセージの一つです。あなたの反逆者は叫び声を与えて、全ての地獄は解放されるところです!

A word to the wise at this point: make sure that if you are stepping on toes, you have some back-up. The
catalyst for a bar room brawl is usually the person with two black eyes. That is what it means to eat


If you do not plan to go to such extremes, Crow reversed may indicate that you are merely "cheating a
little" on your diet, or covertly watching the neighbors have a spat, or thinking, "Prmises are made to
be broken." In any of these situations, the only loser is you. If you are lying to yourself on any level, you have lost the power of Crow. Think about it, and maybe your inner truth will come to you.


Spat ちょっとしたけんか,いさかい.

In seeing what is true, you may need to weed out past beliefs or ideas to bring yourself into the present moment. Contrary Crow speaks of needing to remember that Divine Law is not judgment or denial of self-truths. Divine Law is honoring harmony that comes from a peaceful mind, an open heart, a true tongue, a light step, a forgiving nature, and a love of all living creatures. Honor the past as your teacher, honor the
present as your creation, and honor the future as your inspiration.


Refusing to honor the shifts in your reality can cause emotional pain. An implosion of energy is apparent when rebellion surfaces. Contrary Crow speaks of broken law. The law of expansion is broken by suppression. This may apply to a situation, an old habit, a person you have given your authority to, or your own
fears. It is always your own creation, so call on Crow and shift that creation to your new


Focus on the positive. Detach from negativity. See opportunities in every challenge.


Source: Sams, Jamie and Carson, David. Medicine Cards (Santa Fe: Bear and Company, 1988





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February 06, 2013


Depression or cancer: the choice between serotonin or melatonin?



Panzer A.


Department of Physiology, University of Pretoria, South Africa.



Stress causes disturbances of monoamine functioning and may result in a serotonin deficiency which is manifested, as depression. In some humans, stress does not, however, cause depression.



It is hypothesized that in these individuals, melatonin, which is normally a product of serotonin, may be converted back to its precursor and thus replenish serotonin stores.


These people are thus not depressed and are characterized by their pleasant, unassertive nature. Their lowered melatonin levels may, however, signal an increased risk for cancer.


unassertive nature 穏やかな性質

It is therefore postulated that unresolved stress results in either depression (with low serotonin) or cancer (as a result of decreased melatonin), depending on individual personality traits and biochemistry.






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February 04, 2013

健康と感情:あなたの感情状態によってインフルエンザウイルスに感染しやすくなるかも?MOLECULES OF EMOTION(感情の分子)より

下記の翻訳はMOLECULES OF EMOTION(感情の分子)CANDACE B.PERT,PHD.D(キャンダス・パート博士著)の189ページのHEALTH AND EMOTIONの一部を訳したものです。心の状態とインフルエンザウイルス感染は関係しているみたいです。





ウイルスが細胞内に侵入するために神経ペプチドと同じ受容体を使用します。結合するために特定の受容体に対してどのくらい量の天然ペプチドがまわりあって得られるかによって、その受容体にフィトするウイルスの細胞内侵入は容易にまたは困難になります。感情の分子はウイルスの細胞内侵入に関与するために、私たちの感情状態がウイルスに感染にするかどうかに影響を与えることを仮定することは論理的であります。このことは、ある人は他の人より同じ負荷量のウイルスで病気になる理由を説明するかも知れない。あなたについてはわかりませんが、スキーに行こうとすると病気に罹ったことは決してないです。高揚したムード、エキサイティングな可能性または冒険に対する一つの楽しい予測および望みがあるウイルスに対して予防することができるのか? このことが如何に働くかも知れないことの一つの可能な説明は、主要な精神薬理学理論によると、ウイルス風邪の原因のライノウイルスは心の幸せな状態に流れると考えられる情報物質・ノルアドレナリンの受容体を用いて細胞に侵入します。おそらく、何が起こっているかは、あなたが幸せな時、ノルアドレナリンが全ての潜在的ウイルス受容体をブロックしているためにライノウイルスは細胞内に侵入することができない。



感情の分子(Molecules of Emotion):オピオイド受容体発見者キャンダス・パート博士著紹介









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